This is a course webpage for Biomolecular Control Systems offered in Sem I, 2023-2024.
Abhilash Patel, apatel[at]iitk.ac.in
Shikha Singh Chauhan (shikha22[at]iitk.ac.in), Aditi Saxsena (saditi23[at]iitk.ac.in)
WF, 9.00AM-10.15AM, at ACES 213
| Lecture | Topics | Suggested Readings (/ implies OR) |
|---|---|---|
| 1 | Course Mechanics | FCH |
| 2 | Mass action law, modeling elementary reactions, steady state, stability of steady states | In 2.1/ DeMu 2.1 |
| 3 | Modeling some more elementary reactions, mass conservation, Quasi-Steady state approximation, enzymatic reactions | In 2.1, 2.2, 3.1/ DeMu 2.1 |
| 4 | Central dogma of molecular biology, modeling transcription and translation, regulated gene expression | In 7.1/ DeMu 2.2 |
| 5 | Gene expression as system, cooperative and competitive regulations | In 7.1/ DeMu 2.2 |
| 6 | Tutorial on solving ODEs | Slides by TAs |
| 7 | Genes to motifs to network, negative feedback in engineering systems | In 7.1/ DeMu 2.2 |
| 8 | Negative autoregulation/self feedback, impact on dynamical behaviours, robustness | Al 2/ DeMu 5.2, 3.2, |
| 9 | Negative feedback (contd), Repressilator/oscillations <-> limit cycles | Al 2/ DeMu 5.2, 3.2, 5.4 |
| 10 | Positive feedback, impact on dynamical behaviours, switch<->multistability | Al 5.1/ DeMu 5.3 |