Systems Biology Group
Department of Chemical Engineering, IIT Kanpur"Deciphering the design principles of biological networks through mathematical modeling and computational simulation."
Our Team
Principal Investigator & Research Scholars
Research Focus
Our research group employs a multidisciplinary approach at the interface of chemical engineering, physics, and biology to unravel the complexities of biological systems. By integrating mathematical modeling, statistical mechanics, and computational simulations, we aim to decipher the fundamental design principles that govern cellular behavior, decision-making processes, and robustness in the face of biological noise. We focus on understanding how molecular interactions translate into phenotypic outcomes across various biological scales, from single-cell dynamics to tissue-level organization.
Key Areas of Interest
Stem Cell Systems & Tissue Dynamics
Quantitative modeling of cell fate decisions, proliferation, and differentiation in epidermal, intestinal, and neural stem cell systems. Application of statistical mechanics to understand tissue homeostasis and cancer stem cell dynamics.
Computational Systems Biology
Stochastic and deterministic modeling of regulatory networks and signal transduction pathways (such as EGFR, GPCR, TNF-α, TGF-β, and NF-κB). Analysis of metabolic fluxes (Glycolysis) and biological noise in cellular pathways.
Structural Biology & Therapeutics
Structure-based drug design using Molecular Docking and Molecular Dynamics (MD) simulations to investigate protein-ligand interactions and design inhibitors for therapeutic targets such as CtBP and EGFR kinase domains.
Previous Affiliation
- Post Doctoral Fellow Johns Hopkins School of Medicine (2008)
Education
- Ph.D. in Chemical Engineering State University of New York, Buffalo (2008)
- B.E. in Chemical Engineering University of Roorkee (Now IIT Roorkee) (1998)
Contact
Office: 458, Faculty Building (FB),
Lab: 612, Engineering Science Building 3, (ESB3),
Department of Chemical Engineering
IIT Kanpur, Uttar Pradesh, India, 208016.
Tel: 91-512-259 7605
Fax: 91-512-259 0104
Doctoral Scholars
Masters Scholars
Alumni
Past members and their contributions.
Publications
Recent contributions to the field.
Gallery
Life inside and outside the lab.
Graduating Batch Class of 2025
(Left to right: Shreya, Saumya, Chhavi, Chetan, Hemal, Utkarsh, and Shivanshu)
Teachers' Day 2025
(Left to right: Utkarsh, Saumya, Dr. Raghvendra, and Shreya)
Dr. Raghvendra receiving Excellence in Teaching Award
From Director IIT Kanpur on Sept. 5, 2024, Teachers' Day
Teaching
Courses offered by Dr. Raghvendra Singh