Molecular Oncology Lab

Research Publications (*Corresponding Author)

2021

Transcriptional network involving ERG and AR orchestrates Distal-Less Homeobox-1 mediated prostate cancer progression. Goel S, Bhatia V, Kundu S, Biswas T, Carskadon S, Gupta N, Asim M, Morrissey C, Palanisamy N, Ateeq B*. Nature Communications 2021 Sep 7;12(1):5325. doi: 10.1038/s41467-021-25623-2. Link

Blog on this article: DLX1 is more than just a urinary diagnostic biomarker for prostate cancer. Ateeq B & Goel S. Nature Research Cancer Community. Sept 2021. Link

Press Coverage:            Research Matters            SciSOUP          

Epigenetic reprogramming during prostate cancer progression: A perspective from development. Goel S, Bhatia V, Biswas T, Ateeq B*. Semin Cancer Biol. 2021 Feb 2: S1044-579X (21)00023-7. doi: 10.1021/acs.biochem.0c00661. Link

2020

Computational Design of BH3-Mimetic Peptide Inhibitors That Can Bind Specifically to Mcl-1 or Bcl-XL: Role of Non-Hot Spot Residues. Reddy CN, Manzar N, Ateeq B, Sankararamakrishnan R*. Biochemistry. Nov 2020. doi: 10.1021/acs.biochem.0c00661. Link

Targeting AGTR1/NF-κB /CXCR4 axis by miR-155 attenuates oncogenesis in Glioblastoma. Singh A, Srivastava N, Yadav A, Ateeq B*. Neoplasia. Sept 2020. doi: 10.1016/j.neo.2020.08.002. Link

Press Coverage:            SciSoup-Science Blog            SciSoup-Research video

Dynamics of Cellular Plasticity in Prostate Cancer Progression. Tiwari R, Manzar N, Ateeq B*. Frontiers in Molecular Biosciences. Jul 2020. doi: 10.3389/fmolb.2020.00130. Link

Drosophila model of oral peptide therapeutics for adult Intestinal Stem Cell tumors. Bajpai A, Ahmad QT, Tang HW, Manzar N, Singh V,Thakur A, Ateeq B, Perrimon N, Sinha P. A. Disease Model Mech. June 2020. doi: 10.1242/dmm.044420. Link

Toxicity of exhaust particulates and gaseous emissions from gasohol (ethanol blended gasoline)-fuelled spark ignition engines. 5. Agarwal AK, Singh AP, Gupta T, Agarwal RA, Sharma N, Pandey SK, Ateeq B Environ Sci Process Impacts. Jul 2020. doi: 10.1039/D0EM00082E. Link

Chickpea peel waste as sustainable precursor for synthesis of fluorescent carbon nanotubes for bioimaging application. Singh V, Chatterjee S, Palecha M, Sen P, Ateeq B, Verma V Carbon Letters. May 2020. doi: 10.1007/s42823-020-00156-8. Link

Androgen Deprivation Upregulates SPINK1 Expression and Potentiates Cellular Plasticity in Prostate Cancer. Tiwari R#, Manzar N#, Bhatia V, Yadav A, Nengroo MA, Datta D, Carskadon S, Gupta N, Sigouros M, Khani F, Poutanen M, Zoubeidi A, Beltran H, Palanisamy N, Ateeq B*. Nature Communications. Jan 2020. doi: 10.1038/s41467-019-14184-0 Link
Blog on this article: Elevated levels of SPINK1 governs cellular plasticity and maintains neuroendocrine phenotype in prostate cancer. Ateeq B. Nature Research Cancer Community. Jan 2020. Link

Press Coverage:            The Hindu            Nature India            Wellcome Trust - DBT            Research Matters

Nutritive Vitamins as Epidrugs. Nur SM, Rath S, Ahmad V, Ahmad A, Ateeq B, Khan MI. Crit. Rev. Food Sci. Nutr.. Jan 2020. doi: 10.1080/10408398.2020.1712674 Link

2019

Epigenetic silencing of miRNA-338-5p and miRNA-421 drives SPINK1-positive prostate cancer. Bhatia V#, Yadav A#, Tiwari R, Nigam S, Goel S, Carskadon S, Gupta N, Goel A, Palanisamy N, Ateeq B*. Clinical Cancer Research. May 2019. doi: 10.1158/1078-0432.CCR-18-3230 Link
Commentry on this article: New Hope in Prostate Cancer Precision Medicine? miRNA Replacement and Epigenetics. Bjartell A. Clinical Cancer Research. May 2019. doi: 10.1158/1078-0432.CCR-19-0061 Link

Press Coverage:            The Hindu            Research Matters

Proproliferative Function of Adaptor Protein GRB10 in Prostate Carcinoma. Khan M. I., Al Johani A., Hamid A., Ateeq B., Manzar N., Adhami V. M., Lall R. K., Rath S., Sechi M., Siddiqui I. A., Choudhry H., Zamzami M. A., Havighurst T. C., Huang W., Ntambi J. M., Mukhtar H. The FASEB Journal. Mar 2019. doi: 10.1096/fj.201800265RR Link

Molecular Underpinnings Governing Genetic Complexity of ETS-Fusion-Negative Prostate Cancer. Bhatia V. & Ateeq B. Trends in Molecular Medicine. Nov 2019. doi: 10.1016/j.molmed.2019.07.001 Link

AKT Inhibition Modulates H3K4 Demethylase Levels in PTEN-Null Prostate Cancer. Khan M.I., Hamid A., Rath, S., Ateeq B., Khan Q., Siddiqui I. A., Adhami V. M., Choudhry H., Zamzami M. A., & Mukhtar H. Molecular Cancer Therapeutics. Feb 2019. doi: 10.1158/1535-7163.MCT-18-0141 Link

Implications of the circular RNAs in localized prostate cancer. Nigam S., Manzar N. & Ateeq B. Annals of Translational Medicine. June 2019. doi: 10.21037/atm.2019.07.23 Link

Caspase-3 Mediated Programmed Cell Death by a Gold-Stabilised Peptide Carbene. Gupta A., Nigam S., Avasthi I., Sharma B., Ateeq B. & Verma S. Bioorganic & Medicinal Chemistry Letters. November 2019. doi: 10.1016/j.bmcl.2019.126672 Link

Correction to "Direct Intranuclear Anticancer Drug Delivery via Polydimethylsiloxane Nanoparticles: in Vitro and in Vivo Xenograft Studies." Mishra G, Bhattacharyya S, Bhatia V, Ateeq B, Sharma A, Sivakumar S*. ACS Applied Materials and Interfaces. October 2019. doi:doi.org/10.1021/acsami.9b17603. Link

2018

Mutagenicity and Cytotoxicity of Particulate Matter Emitted from Biodiesel-Fueled Engines. Agarwal AK*, Singh AP, Gupta T, Agarwal RA, Sharma N, Rajput P, Pandey SK, Ateeq B. Environmental Science and Technology. Volume 52 (24), pp 14496-14507, December 2018. doi.10.1021/acs.est.8b03345 Link

AKT Inhibition Modulates H3K4 Demethylase Levels in PTEN-Null Prostate Cancer. Khan MI*, Hamid A, Rath S, Ateeq B, Khan Q, Siddiqui IA, Adhami VM, Choudhry H, Zamzami MA, Mukhtar H. Molecular Cancer Therapeutics. November 2018. doi: 10.1158/1535-7163.MCT-18-0141. Link

Pro-proliferative function of adaptor protein GRB10 in prostate carcinoma. Khan MI*, Al Johani A, Hamid A, Ateeq B, Manzar N, Adhami VM, Lall RK, Rath S, Sechi M, Siddiqui IA, Choudhry H, Zamzami MA, Havighurst TC, Huang W, Ntambi JM, Mukhtar H. The FASEB Journal. Volume 33, pp.fj-201800265RR, October 2018. doi.org/10.1096/fj.201800265RR. Link

Entropically driven controlled release of paclitaxel from poly(2-ethyl-2-oxazoline) coated maghemite nanostructures for magnetically guided cancer therapy. Kumar N, Tyeb S, Manzar N, Behera L, Ateeq B, Verma V* Soft Matter. Volume 14(31), pp 6537-6553, 2018 Aug 21. doi: 10.1039/c8sm01220b. Link

Toxicity and mutagenicity of exhaust from compressed natural gas: Could this be a clean solution for megacities with mixed-traffic conditions? Agarwal AK*, Ateeq B, Gupta T, Singh AP, Pandey SK, Sharma N, Agarwal RA, Gupta NK, Sharma H, Jain A, Shukla PC Environmental Pollution. Volume 239, pp 499-51111(2), April 2018. doi.org/10.1016/j.envpol.2018.04.028. Link

Association of AGTR1 (A1166C) and ACE (I/D) Polymorphisms with Breast Cancer Risk in North Indian Population. Singh A, Shrivastava N, Amit S, Prasad SN, Mishra MP, Ateeq B*. Translational Oncology. 11(2), pp 233-242, April 2018. doi:10.1016/j.tranon.2017.12.007. Link

2017

Direct Intranuclear Anticancer Drug Delivery via Polydimethylsiloxane Nanoparticles: in Vitro and in Vivo Xenograft Studies. Mishra G, Bhattacharyya S, Bhatia V, Ateeq B, Sharma A, Sivakumar S*. ACS Applied Materials and Interfaces. 9 (40), pp 34625-34633, September 13, 2017. doi:10.1021/acsami.7b08806. Link

Targeting NF-kappa B signaling by Artesunate restores sensitivity of castrate-resistant prostate cancer cells to anti-androgens. Nunes JJ#, Pandey SK#, Yadav A#, Goel S, Ateeq B*. Neoplasia. vol 19 (4), p333-345, 2017 April. doi:10.1016/j.neo.2017.02.002. (#Equal contribution first author) Link

Press Coverage:            Business Standard            India.com            CanIndia            Wellcome Trust-DBT

Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Product in Prostate Cancer. Wang X, Qiao Y, Asangani IA, Ateeq B, Poliakov A, Cieslik M, Pitchiaya S, Chakravarthi BVSK, Cao X, Jing X, Wang CX, Apel IJ, Wang R, Tien JC, Juckette KM, Yan W, Jiang H, Wang S, Varambally S, Chinnaiyan AM*. Cancer Cell. vol 31, p1-17, 2017 April 10. doi:10.1016/j.ccell.2017.02.017. Link

Press Coverage:            Bioscience Technology            Medical Express            Heal Alerts           

Ag/AgO Nanoparticles Grown via Time Dependent Double Mechanism in a 2D Layered Ni-PCP and Their Antibacterial Efficacy. Agarwal RA*, Gupta NK, Singh R, Nigam S, Ateeq B. Scientific Reports. vol 7, 2017 March 21. doi:10.1038/srep44852. Link

2016

Molecular Discriminators of Racial Disparities in Prostate Cancer. Ateeq B*, Goel S, Bhatia V. Trends in Cancer. vol 2 (3), p116-120, 2016 March. doi:10.1016/j.trecan.2016.01.005. Link

2015

SPINK1 promotes colorectal cancer progression by downregulating Metallothioneins expression. Tiwari R#, Pandey SK#, Goel S, Bhatia V, Shukla S, Jing X, Dhanasekaran SM, Ateeq B*. Oncogenesis. 2015 Aug 10;4:e162. doi: 10.1038/oncsis.2015.23. (#Equal contribution first author) Link

Press Coverage:            India Bioscience            NDTV            India Medical Times            Wellcome Trust-DBT

Molecular Profiling of ETS and Non-ETS Aberrations in Prostate Cancer Patients from Northern India. Ateeq B*, Kunju LP, Carskadon SL, Pandey SK, Singh G, Pradeep I, Tandon V, Singhai A, Goel A, Amit S, Agarwal A, Dinda AK, Seth A, Tsodikov A, Chinnaiyan AM, Palanisamy N. Prostate. 2015 Jul 1;75(10):1051-62. doi: 10.1002/pros.22989. Link

Press Coverage:            NDTV            Deccan Herald            India Medical Times            Zee News

Role and therapeutic potential of G-protein coupled receptors in Breast Cancer progression and metastases. Singh A, Nunes JJ, Ateeq B*. Eur. J. Pharmacol. 2015 Sep 15;763(Pt B):178-83. doi: 10.1016/j.ejphar.2015.05.011 Link.

2013

The role of sarcosine metabolism in prostate cancer progression. Khan AP, Rajendiran TM, Ateeq B, Asangani IA, Athanikar JN, Yocum AK, Mehra R, Siddiqui J, Palapattu G, Wei JT, Michailidis G, Sreekumar A, Chinnaiyan AM*. Neoplasia. 2013 May; 15(5):491-501. Link.

Identification of Targetable FGFR Gene Fusions in Diverse Cancers. Wu YM, Su F, Kalyana-Sundaram S, Khazanov N, Ateeq B, Cao X, Lonigro RJ, Vats P, Wang R, Lin SF, Cheng AJ, Kunju LP, Siddiqui J, Tomlins SA, Wyngaard P, Sadis S, Roychowdhury S, Hussain M, Feng FY, Zalupski MM, Talpaz M, Pienta KJ, Rhodes DR, Robinson DR, Chinnaiyan AM*. Cancer Discov. 2013 Apr 4. Link.

Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer. Asangani IA, Ateeq B, Cao Q, Dodson L, Pandhi M, Kunju LP, Mehra R, Lonigro RJ, Siddiqui J, Palanisamy N, Wu YM, Cao X, Kim JH, Zhao M, Qin ZS, Iyer MK, Maher CA, Kumar-Sinha C, Varambally S, Chinnaiyan AM*. Mol Cell. 2013 Jan 10;49(1):80-93. ) Link.

2012

Role of Transcriptional Co-Repressor CtBP1 in Prostate Cancer Progression. Wang R, Asangani IA, Chakravarthi BV, Ateeq B, Lonigro RJ, Cao Q, Mani RS, Camacho DF, McGregor N, Schumann TE, Jing X, Menawat R, Tomlins SA, Zheng H, Otte AP, Mehra R, Siddiqui J, Dhanasekaran SM, Nyati MK, Pienta KJ, Palanisamy N, Kunju LP, Rubin MA, Chinnaiyan AM*, Varambally S*. Neoplasia. Oct. 2012 vol. 14(10): 905-914. Link.

The Mutational Landscape of Lethal Castrate Resistant Prostate Cancer. Grasso CS#, Wu YM#, Robinson DR#, Cao X, Dhanasekaran SM, Khan AP, Quist MJ, Jing X, Lonigro RJ, Brenner JC, Asangani IA, Ateeq B, Chun SY, Siddiqui J, Sam L, Anstett M, Mehra R, Prensner JR, Palanisamy N, Ryslik GA, Vandin F, Raphael BJ, Kunju LP, Rhodes DR, Pienta KJ, Chinnaiyan AM*, Tomlins SA*. Nature. 2012 Jul 12; 487(7406):239-43. Link.

Role of Dutasteride in Pre-Clinical ETS- Fusion Positive Prostate Cancer Models. Ateeq B, Vellaichamy A, Tomlins SA, Wang R, Cao Q, Lonigro RJ, Pienta KJ, Varambally S*. Prostate. 2012 Mar 13. doi: 10.1002/pros.22509. Link.

2011

Therapeutic targeting of SPINK1-positive prostate cancer. Ateeq B, Tomlins SA, Laxman B, Asangani IA, Cao Q, Cao X, Li Y, Wang X, Feng FY, Pienta KJ, Varambally S, Chinnaiyan AM*. Science Translational Medicine. 2011 Mar 2; 3(72):72ra17. Link.

Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion Positive Prostate Cancer. Brenner JC#, Ateeq B#, Li Y, Yocum AK, Cao Q, Asangani IA, Patel S, Wang X, Liang H, Yu J, Palanisamy N, Siddiqui J, Yan W, Cao X, Mehra R, Sabolch A, Basrur V, Lonigro RJ, Yang J, Tomlins SA, Maher CA, Elenitoba-Johnson KS, Hussain M, Navone NM, Pienta KJ, Varambally S, Feng FY, Chinnaiyan AM*. Cancer Cell. 2011 May 17; 19(5):664-78. (#Equal contribution first author). Featured on Cover. Link.

Functionally Recurrent Rearrangements of the MAST Kinase and Notch Gene Families in Breast Cancer. Robinson DR#, Kalyana-Sundaram S#, Wu YM, Shankar S, Cao X, Ateeq B, Asangani IA, Iyer M, Maher CA, Grasso CS, Lonigro RJ, Quist M, Siddiqui J, Mehra R, Jing X, Giordano TJ, Sabel MS, Kleer CG, Palanisamy N, Natrajan R, Lambros MB, Reis-Filho JS, Kumar-Sinha C, Chinnaiyan AM*. Nature Medicine. 2011 Nov 20; 17(12):1646-51. Link.

Coordinated Regulation of Polycomb Group Complexes Through microRNAs in Cancer. Cao Q, Mani RS, Ateeq B, Dhanasekaran SM, Asangani IA, Prensner JR, Kim JH, Brenner JC, Jing X, Cao X, Wang R, Li Y, Dahiya A, Wang L, Pandhi M, Lonigro RJ, Wu YM, Tomlins SA, Palanisamy N, Qin Z, Yu J, Maher CA, Varambally S, Chinnaiyan AM*. Cancer Cell. 2011 Aug 16; 20(2):187-99. Link.

Characterization of KRAS Rearrangements in Metastatic Prostate Cancer. Wang XS#, Shankar S#, Dhanasekaran SM#, Ateeq B, Sasaki AT, Jing X, Robinson D, Cao Q, Prensner JR, Yocum AK, Wang R, Fries DF, Han B, Asangani IA, Cao X, Li Y, Omenn GS, Pflueger D, Gopalan A, Reuter VE, Kahoud ER, Cantley LC, Rubin MA, Palanisamy N, Varambally S, Chinnaiyan AM*. Cancer Discovery. 2011 Jun 1;1(1):35-43. Link.

2010

Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma. Palanisamy N#, Ateeq B#, Kalyana-Sundaram S#, Pflueger D, Ramnarayanan K, Shankar S, Han B, Cao Q, Cao X, Suleman K, Kumar-Sinha C, Dhanasekaran SM, Chen YB, Esgueva R, Banerjee S, LaFargue CJ, Siddiqui J, Demichelis F, Moeller P, Bismar TA, Kuefer R, Fullen DR, Johnson TM, Greenson JK, Giordano TJ, Tan P, Tomlins SA, Varambally S, Rubin MA, Maher CA, Chinnaiyan AM*. Nature Medicine. 2010 Jul; 16 (7):793-8. (#Equal contribution first author). Link.

An anti-urokinase receptor (uPAR) antibody (ATN-658) blocks prostate cancer invasion, migration, growth and experimental skeletal metastasis in vitro and in vivo. Rabbani SA*, Ateeq B, Arakelian A, Valentino ML, Shaw DE, Dauffenbach LM, Kerfoot CA, Mazar AP. Neoplasia. 2010 Oct. 12(10): 778-88. Featured on Cover. Link.

2009

AGTR1 as a therapeutic target in ER-positive and ERBB2-negative breast cancer cases. Ateeq B, Tomlins SA, Chinnaiyan AM*. Cell Cycle. 2009 Dec; 8(23):3794-5. Link.

AGTR1 over-expression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonist. Rhodes DR#, Ateeq B#, Cao Q#, Tomlins SA#, Mehra R, Laxman B, Kalyana-Sundaram S, Lonigro RJ, Helgeson BE, Bhojani MS, Rehemtulla A, Kleer CG, Hayes DF, Lucas PC, Varambally S, Chinnaiyan AM*. Proc Natl Acad Sci USA 2009 Jun 23; 106(25):10284-9. (#Equal contribution first author). Link.

2008

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Varambally S, Cao Q, Mani RS, Shankar S, Wang X, Ateeq B, Laxman B, Cao X, Jing X, Ramnarayanan K, Brenner JC, Yu J, Kim JH, Han B, Tan P, Kumar-Sinha C, Lonigro RJ, Palanisamy N, Maher CA, Chinnaiyan AM*. Science. 2008, 12;322(5908):1695-9. Faculty of 1000 Biology: Exceptional. Link.

Pharmacological inhibition of DNA methylation induces pro-invasive and pro-metastatic genes in vitro and in vivo. Ateeq B, Unterberger A, Szyf M, Rabbani SA. Rabbani*. Neoplasia. 2008; 10(3):266-78. Link.

Molecular profiling of genes in squamous cell lung carcinoma in Asian Indians. Sen S, Ateeq B, Sharma H, Datta P, Gupta SD, Bal S, Kumar A, Singh N*. Life Sciences. 2008; 82(13-14):772-9. Link.

2006 - 2007

Evidence of apoptotic effects of 2,4-D and butachlor on walking catfish, Clarias batrachus, by transmission electron microscopy and DNA degradation studies. Ateeq B*, Abul Farah M, Ahmad W. Life Sciences.2006;78(9):977-86. Link.

Antimutagenic effect of neem leaves extract in freshwater fish, Channa punctatus evaluated by cytogenetic tests. Farah MA*, Ateeq B, Ahmad W. Science of Total Environment. 2006; 364(1-3):200-14. Link.

Detection of DNA damage by single cell gel electrophoresis in 2,4-D and butachlor exposed erythrocytes of Clarias batrachus. Ateeq B*, Farah MA, Ahmad W. Ecotoxicology and Environmental Safety. 2006; 62(3):348-54. Link.

2004 - 2005

Studies on lethal concentrations and toxicity stress of some chlorinated xenobiotics on non-target organisms. Farah MA, Ateeq B, Ali MN, Sabir R, Ahmad W*. Chemosphere. 2004; 55:257-265. Link.

2002 - 2003

Evaluation of genotoxicity of PCP and 2,4-D by micronucleus test in freshwater fish Channa punctatus. Ecotoxicology and Environmental Safety. Farah MA, Ateeq B, Ali MN, Ahmad W*. 2003; 54(1): 25-29. Link.

Induction of micronuclei and erythrocyte alterations in the catfish Clarias batrachusby 2,4-dichlorophenoxyacatic acid and butachlor. Ateeq B, Farah MA, Ali MN, Ahmad W*. Mutation Research. 2002; 518(2): 135-144. Link.

Clastogenicity of pentachlorophenol, 2, 4-D and butachlor evaluated by Allium root tip test. Ateeq B, Farah MA, Ali MN, Ahmad W*. Mutation Research. 2002; 514: 105-113. Link.

Computerized automated morphometric assay including frequency estimation of pentachlorophenol induced nuclear anomalies (micronuclei) in catfish Heteropneustes fossilis. Ahmad W*, Ali MN, Farah MN, Ateeq B. Chromosoma. 2002; 110: 570-574. Link.