The JKB Group                  

                                                                                                                                      Department of Chemistry

                                                                                                                                           Indian Institute of Technology Kanpur, India

 

Inorganic and Organometallic Chemistry

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Research Highlighted on Journal Cover Page

  

Bera group at IIT Kanpur studies organometallic catalysts for small molecule activation and organic transformations. Towards this effort, organometallic compounds based on bimetallic constructs (M-M) are developed and their catalytic utility in organic reactions is explored. Dicopper (I), diruthenium (I) and dipalladium(I) compounds are synthesized which show excellent catalytic activity for cycloaddition, carbene transfer and C-C coupling reactions, respectively. Carefully designed experiments reveal that metal-metal cooperation influences substrate activation, guides stereoelectronic factors and promotes product elimination in the catalytic cycle. Lessons learnt from these studies are utilized to develop new-generation catalysts for conversion of cheap and abundant molecules to useful chemicals.

Another key area of research that is being developed at Kanpur includes designed catalysts featuring metal-ligand (M-L) cooperation. Carefully designed ligand scaffold which holds the metal ion and simultaneously offers proton-acceptor has been devised for bifunctional water activation. Using this principle, hydration, hydrolytic and oxidation catalysts that utilize water as a reagent is developed. The metal-ligand cooperation strategy is a simple and effective paradigm in small-molecule-activation chemistry. Importantly, it involves bifunctional substrate activation, and not necessarily oxidative addition/reductive elimination sequence, thus offering prospect for catalysts based on 3d metals.  We are presently developing catalysts that employ hydroxy / hydroxide and amine / amide functionality for activation of alcohol and hydrogen respectively.

Further, we seek to understand fundamental processes involved in organometallic reactions. Activation of C-H bond has remained a favorite topic in our research.

A host of experimental techniques including X-ray, NMR, GC-MS, kinetic studies, isotope labeling experiments are routinely carried out for compound characterization, and for studying reaction mechanism. Computational tools are often exploited to support proposed pathway. Through such unifying approaches, Bera group seeks to gain clear mechanistic understanding of chemical processes.

Recently, we have initiated a green chemistry program to address energy, environmental and sustainability aspects of chemical synthesis.

 

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(1) J. Am. Chem. Soc. 2015, 137, 6168. (2) J. Am. Chem. Soc. 2014,136, 13987. (3)  Chem. Eur. J. 2014, 20, 16537. (4)  Chem. Eur. J. 2014, 20, 6542. (5) Tetrahedron Lett. 2014, 55, 1444. (6) J. Organomet. Chem. 2014, 771, 124. (7) Chem. Commun., 2013, 49, 9764. (8) Organometallics 2013, 32, 4306. (9) Inorg. Chem. 2013, 52, 1432. (10)  Organometallics 2013, 32, 340. (11)  Organometallics 2013, 32, 192. (12) Organometallics 2012, 31, 5533. (13)  Organometallics 2012, 31, 5500. (14) Organometallics 2012, 31, 3790. (15) Organometallics, 2011, 30, 2051. (16)  Chem. Eur. J., 2010, 16, 14459. (17) Chem. Eur. J. 2010, 16, 2574. (18) Inorg. Chem. 2008, 47, 2212. (19) Chem. Commun. 2008, 2511. (20) Organometallics, 2006, 25, 6054. (21) Organometallics, 2007, 26, 2598. (22) J. Organomet. Chem. 2011, 696, 1248. (23) Eur. J. Inorg. Chem. 2009, 4023. (24) Inorg. Chem. 2009, 48, 11114. (25) Eur. J. Inorg. Chem. 2012, 1680. (26) Inorg. Chem. 2009, 48, 978. (27) Organometallics, 2006, 25, 2914. (28) Chem. Commun., 2011, 47, 10836. (29) Inorg. Chem. 2012, 51, 1319.

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      Updated on June, 2015